How to Use the Program
Participating specialty pharmacies must complete a 1-time registration so they may process Evrysdi Co-pay Program* payments. To register, call (800) 636-0316.
The provider sends the prescription. Either the provider or patient sends the patient's Member ID number and Rx BIN to the specialty pharmacy.
The specialty pharmacy collects the patient's co-pay.
The specialty pharmacy uses the Rx BIN to process the Evrysdi Co-pay Program as secondary insurance and ships Evrysdi to the patient.
The Evrysdi Co-pay Program reimburses the specialty pharmacy for the patient's out-of-pocket costs for Evrysdi.
*Eligible commercially insured patients who are prescribed Evrysdi for an FDA-approved use can receive up to $25,000 in assistance per calendar year for drug costs.
Evrysdi is indicated for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients.
Important Safety Information
Interactions with Substrates of MATE Transporters
- Based on in vitro data, Evrysdi may increase plasma concentrations of drugs eliminated via MATE1 or MATE2-K, such as metformin
- Avoid coadministration of Evrysdi with MATE (multidrug and toxin extrusion) substrates. If coadministration cannot be avoided, monitor for drug-related toxicities and consider dosage reduction of the coadministered drug if needed
Pregnancy & Breastfeeding
- Evrysdi may cause embryofetal harm when administered to a pregnant woman. In animal studies, administration of Evrysdi during pregnancy and/or lactation resulted in adverse effects on development. Advise pregnant women of the potential risk to the fetus
- Pregnancy testing is recommended prior to initiating Evrysdi. Advise female patients to use contraception during treatment with Evrysdi and for at least 1 month after the last dose
- The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Evrysdi and any potential adverse effects on the breastfed infant
Potential Effects on Male Fertility
- Counsel male patients that fertility may be compromised by treatment with Evrysdi. Male patients may consider sperm preservation prior to treatment
Most Common Adverse Reactions
- The most common adverse reactions in later-onset SMA (incidence in at least 10% of patients treated with Evrysdi and more frequent than control) were fever, diarrhea, and rash
- The most common adverse reactions in infantile-onset SMA were similar to those observed in later-onset SMA patients. Additionally, adverse reactions with an incidence of at least 10% were upper respiratory tract infection (including nasopharyngitis, rhinitis), lower respiratory tract infection (including pneumonia, bronchitis), constipation, vomiting, and cough
- The safety profile for presymptomatic patients is consistent with the safety profile for symptomatic SMA patients treated with Evrysdi in clinical trials
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see accompanying full Prescribing Information for additional Important Safety Information.